RESEARCH

Welcome to the Hruska lab, where we delve into the intricate world of synaptic function and dysfunction in the central nervous system (CNS). Synapses, the fundamental structures facilitating information transfer and brain plasticity, are at the heart of our research.

Our overarching goal is to decipher the complex biology of synapses and its implications for neurological disorders. Through a multidisciplinary approach integrating molecular and biochemical methods with state-of-the-art Stimulated Emission Depletion (STED) microscopy, we focus on three core domains:

1. Nanoscale Molecular Organization: Unraveling the intricate molecular architecture of active zones and post-synaptic densities.

2. Synaptic Plasticity Mechanisms: Investigating the dynamic processes underlying synaptic adaptation and plasticity.

3. Neurological Disorder Pathogenesis: Exploring how synaptic dysfunction contributes to the pathogenesis of neurological disorders.

Join us as we unravel the mysteries of synaptic biology, advancing our understanding of brain function and pathology.