HRUSKA LAB
The super-resolution imaging group
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martin.hruska@hsc.wvu.edu
Akter Y, Jones G, Daskivich GJ, Shifflett V, Vargas KJ, Hruska M (2025) Combining nanobody labeling with STED microscopy reveals input-specific and layer-specific organization of neocortical synapses. PLoS Biol 23(4): e3002649. https://doi.org/10.1371/journal.pbio.3002649
Huhn, C. et al. eSylites: Synthetic Probes for Visualization and Topographic Mapping of Single Excitatory Synapses. J. Am. Chem. Soc. (2025) doi:10.1021/jacs.5c00772.
Jones, G., Akter, Y., Shifflett, V. & Hruska, M. Nanoscale analysis of functionally diverse glutamatergic synapses in the neocortex reveals input and layer-specific organization. BioRxiv preprint available at: https://doi.org/10.1101/2024.05.01.592008
Manning A., Bender P.T.R, Boyd-Pratt H., Mendelson B. Z., Hruska M., Anderson C.T. Trans-synaptic association of vesicular zinc transporter 3 and Shank3 supports synapse-specific dendritic spine structure and function in mouse auditory cortex. J. Neurosci. e0619242024 (2024) doi:10.1523/jneurosci.0619-24.2024.
Hruska, M., Cain, R. E. & Dalva, M. B. Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific. Nat Commun 13, 920 (2022)
Henderson, N. T. et al. Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. eLife 8, e41563 (2019)
Hruska, M., Henderson, N., Marchand, S. J. L., Jafri, H. & Dalva, M. B. Synaptic nanomodules underlie the organization and plasticity of spine synapses. Nature Neuroscience 21, 671–682 (2018)
Barber, K. R. et al. Levels of Par-1 kinase determine the localization of Bruchpilot at the Drosophila neuromuscular junction synapses. Scientific Reports 8, 16099 (2018)
Hruska, M., Henderson, N. T., Xia, N. L., Marchand, S. J. & Dalva, M. B. Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3. Nature Neuroscience 18, 1594–605 (2015)
Dai, J. et al. Neuron glia-related cell adhesion molecule (NrCAM) promotes topographic retinocollicular mapping. PloS one 8, e73000 (2013).
Hruska, M. & Dalva, M. B. Ephrin regulation of synapse formation, function and plasticity. Molecular and cellular neurosciences 50, 35–44 (2012)
Nolt, M. J. et al. EphB controls NMDA receptor function and synaptic targeting in a subunit-specific manner. The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 5353–64 (2011)
Kayser, M. S., Lee, A. C., Hruska, M. & Dalva, M. B. Preferential control of basal dendritic protrusions by EphB2. PloS one 6, e17417 (2011)
McClelland, A. C., Hruska, M., Coenen, A. J., Henkemeyer, M. & Dalva, M. B. Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling. Proceedings of the National Academy of Sciences of the United States of America 107, 8830–5 (2010)
Nishi, R. et al. The cortistatin gene PSS2 rather than the somatostatin gene PSS1 is strongly expressed in developing avian autonomic neurons. The Journal of Comparative Neurology 518, 839–50 (2010)
Hruska, M. et al. Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 14847–54 (2009)
Hruska, M. & Nishi, R. Cell-autonomous inhibition of alpha 7-containing nicotinic acetylcholine receptors prevents death of parasympathetic neurons during development. The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 11501–9 (2007)
